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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3353
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plod2
Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plod2decreases methylationISOPLOD2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of PLOD2 5' UTR; Benzo(a)pyrene results in decreased methylation of PLOD2 promoterPMID:27901495
Plod2increases expressionISOPlod2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of PLOD2 mRNAPMID:19770486
Plod2increases expressionISOPLOD2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of PLOD2 mRNAPMID:32234424
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