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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3353
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plod2
Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plod2multiple interactionsEXP 6480464CTD[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of PLOD2 mRNAPMID:32741896
Plod2affects expressionISOPLOD2 (Homo sapiens)6480464CTDEstradiol affects the expression of PLOD2 mRNAPMID:14699072
Plod2increases expressionISOPlod2 (Mus musculus)6480464CTDEstradiol results in increased expression of PLOD2 mRNAPMID:19484750
Plod2increases expressionISOPLOD2 (Homo sapiens)6480464CTDEstradiol results in increased expression of PLOD2 mRNAPMID:20106945
Plod2multiple interactionsISOPLOD2 (Homo sapiens)6480464CTD[Estradiol binds to ESR2 protein] which results in increased expression of PLOD2 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of PLOD2 mRNAPMID:20404318 PMID:30165855
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