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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plin1
Name: perilipin 1
Acc ID: CHEBI:8228
Term: pioglitazone
Definition: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Chemical ID: MESH:C060836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plin1multiple interactionsISOPlin1 (Mus musculus)6480464CTD[N-nitroso-tris-chloroethylurea co-treated with Pioglitazone] results in decreased expression of PLIN1 mRNA; Pioglitazone promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PLIN1 mRNA]PMID:27935865 PMID:32473317
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