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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3309
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pfkfb2
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pfkfb2decreases activityEXP 6480464CTDStreptozocin results in decreased activity of PFKFB2 proteinPMID:10700396
Pfkfb2multiple interactionsEXP 6480464CTDLithium Carbonate inhibits the reaction [Streptozocin results in decreased activity of PFKFB2 protein]PMID:10700396
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