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GENE - TERM ANNOTATION REPORT

RGD ID: 3285
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdgfrb
Name: platelet derived growth factor receptor beta
Acc ID: DOID:0111344
Term: myeloproliferative disorder with eosinophilia
Definition: A myeloproliferative neoplasm characterized by chronic proliferation of myeloid cells and eosinophilia in the peripheral blood and bone marrow that has_material_basis_in a fusion of the ETV6 and PDGFRB genes formed by a translocation from chromosome 12 to chromosome 5q32. (DO)
Definition Source(s): PMID:12181402 "DO" "DO", PMID:8168137 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdgfrb ISOPDGFRB (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: EOSINOPHILS, MALIGNANT PROLIFERATION OF | ClinVar Annotator: match by term: Myeloproliferative disorder, chronic, with eosinophiliaPMID:25454926 PMID:25741868 PMID:26455322 PMID:28492532 PMID:29226947 PMID:30573803
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