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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3285
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdgfrb
Name: platelet derived growth factor receptor beta
Acc ID: CHEBI:23414
Term: copper(II) sulfate
Definition: A metal sulfate compound having copper(2+) as the metal ion.
Chemical ID: MESH:D019327
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdgfrbdecreases expressionISOPDGFRB (Homo sapiens)6480464CTDCopper Sulfate results in decreased expression of PDGFRB mRNAPMID:19549813
Pdgfrbincreases expressionISOPDGFRB (Homo sapiens)6480464CTDCopper Sulfate results in increased expression of PDGFRB mRNA; Copper Sulfate results in increased expression of PDGFRB proteinPMID:23392711
Pdgfrbmultiple interactionsISOPDGFRB (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB mRNA]; Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB protein]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB mRNA]]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB protein]]PMID:23392711
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