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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3258
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pax6
Name: paired box 6
Acc ID: CHEBI:73044
Term: lumiracoxib
Definition: An amino acid that is phenylacetic acid which is substituted at position 2 by the nitrogen of 2-chloro-6-fluoroaniline and at position 5 by a methyl group. A highly selective cyclooxygenase 2 inhibitor, it was briefly used for the treatment of osteoarthritis, but was withdrawn due to concersns of hepatotoxicity.
Chemical ID: MESH:C473384
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pax6multiple interactionsISOPax6 (Mus musculus)6480464CTDlumiracoxib affects the reaction [Crotoxin results in increased expression of PAX6 protein]PMID:36702313
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