A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Chemical ID:
MESH:D009020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
[beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of 3,4-Dihydroxyphenylacetic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; [Morphine binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; [naloxonazine binds to and results in decreased activity of OPRM1 protein] which affects the susceptibility to Morphine; [naloxonazine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Morphine binds to and affects the activity of OPRM1 protein; Morphine binds to and results in increased activity of OPRM1 protein
[Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein; [phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; [Zymosan co-treated with Morphine] results in increased expression of OPRM1 mRNA; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]; Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Morphine binds to and affects the activity of OPRM1 protein; Morphine binds to and results in increased activity of OPRM1 protein; Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]; Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]; Naloxone inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]; OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IFNG]; OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IL2]; Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; valyl-prolyl-aspartyl-prolyl-arginine inhibits the reaction [Morphine results in increased activity of OPRM1 protein]
[[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; [[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; [COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine; [OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein; Morphine binds to and results in increased activity of OPRM1 protein; Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]]; OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein]
