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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3159
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nefh
Name: neurofilament heavy chain
Acc ID: CHEBI:75701
Term: sarin
Definition: A racemate composed of equal amounts of (R)- and (S)-sarin. A potent and irreversible inhibitor of acetylcholinesterase that is toxic to the nervous system and is employed as a chemical warfare agent.
Chemical ID: MESH:D012524
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nefhdecreases expressionEXP 6480464CTDSarin results in decreased expression of NEFH mRNAPMID:16733813
Nefhincreases phosphorylationEXP 6480464CTDSarin results in increased phosphorylation of NEFH proteinPMID:21439362
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