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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3159
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nefh
Name: neurofilament heavy chain
Acc ID: CHEBI:16794
Term: scopolamine
Definition: A tropane alkaloid that is the (S)-tropic acid ester of 6beta,7beta-epoxy-1alphaH,5alphaH-tropan-3alpha-ol.
Chemical ID: MESH:D012601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nefhdecreases expressionISONEFH (Homo sapiens)6480464CTDScopolamine results in decreased expression of NEFH proteinPMID:22096544
Nefhmultiple interactionsISONEFH (Homo sapiens)6480464CTDAshwagandha inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]PMID:22096544
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