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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad3
Name: SMAD family member 3
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad3decreases expressionISOSMAD3 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of SMAD3 mRNA; Arsenic Trioxide results in decreased expression of SMAD3 proteinPMID:25196641 PMID:25304214 PMID:34108876
Smad3decreases response to substanceISOSMAD3 (Homo sapiens)6480464CTDSMAD3 protein results in decreased susceptibility to Arsenic TrioxidePMID:20707922
Smad3increases expressionISOSMAD3 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of SMAD3 mRNAPMID:29633893
Smad3multiple interactionsISOSMAD3 (Homo sapiens)6480464CTD[Arsenic Trioxide results in increased expression of MIR491 mRNA] which results in decreased expression of SMAD3 mRNA; Arsenic Trioxide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of SMAD3 protein]; Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; Arsenic Trioxide results in increased expression of and results in increased phosphorylation of SMAD3 protein; Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; MIR491 affects the reaction [Arsenic Trioxide results in decreased expression of SMAD3 mRNA]; MIR491 mRNA promotes the reaction [Arsenic Trioxide results in decreased expression of SMAD3 mRNA]; SMAD3 protein promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]; SMAD3 protein promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]PMID:21649584 PMID:24762191 PMID:25196641 PMID:25304214 PMID:30317545 PMID:35276128
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