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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 30302202
Species: Homo sapiens
RGD Object: Gene
Symbol: PDXK
Name: pyridoxal kinase
Acc ID: CHEBI:17310
Term: pyridoxal
Definition: A pyridinecarbaldehyde that is pyridine-4-carbaldehyde bearing methyl, hydroxy and hydroxymethyl substituents at positions 2, 3 and 5 respectively. The 4-carboxyaldehyde form of vitamin B6, it is converted into pyridoxal phosphate, a coenzyme for the synthesis of amino acids, neurotransmitters, sphingolipids and aminolevulinic acid.
Chemical ID: MESH:D011730
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PDXKincreases phosphorylationEXP 6480464CTDPDXK protein results in increased phosphorylation of PyridoxalPMID:18346762
PDXKmultiple interactionsEXP 6480464CTDpyridoxal phosphate gamma-aminobutyric acid inhibits the reaction [PDXK protein results in increased phosphorylation of Pyridoxal]PMID:18346762
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