Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	3006
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Lhb
Name:	luteinizing hormone subunit beta

Acc ID:	CHEBI:6413
Term:	letrozole
Definition:	A triazole that has formula C17H11N5.
Chemical ID:	MESH:C067431

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Lhb	increases expression	EXP		6480464	CTD	Letrozole results in increased expression of LHB protein	PMID:28619389 PMID:33491863 PMID:39032681
Lhb	increases secretion	EXP		6480464	CTD	Letrozole results in increased secretion of LHB protein	PMID:31295448 PMID:32298659
Lhb	multiple interactions	EXP		6480464	CTD	indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of LHB protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of LHB protein]]; LHB protein inhibits the reaction [Letrozole results in increased expression of LHB protein]; Linagliptin inhibits the reaction [Letrozole results in increased expression of LHB protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of LHB protein]]; Metformin inhibits the reaction [Letrozole results in increased secretion of LHB protein]; N(1)-methylnicotinamide inhibits the reaction [Letrozole results in increased secretion of LHB protein]; Niacinamide inhibits the reaction [Letrozole results in increased secretion of LHB protein]; Saccharin promotes the reaction [Letrozole results in increased expression of LHB protein]; Spironolactone inhibits the reaction [Letrozole results in increased secretion of LHB protein]	PMID:28619389 PMID:31295448 PMID:32298659 PMID:33491863 PMID:39032681
Lhb	increases expression	ISO	Lhb (Mus musculus)	6480464	CTD	Letrozole results in increased expression of LHB protein	PMID:37030623
Lhb	increases expression	ISO	LHB (Homo sapiens)	6480464	CTD	letrozole results in increased expression of LHB protein	PMID:15123030 PMID:16046582
Lhb	multiple interactions	ISO	Lhb (Mus musculus)	6480464	CTD	diacerein inhibits the reaction [Letrozole results in increased expression of LHB protein]	PMID:37030623

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