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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3006
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lhb
Name: luteinizing hormone subunit beta
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lhbincreases expressionEXP 6480464CTDGlyphosate results in increased expression of LHB mRNA; Glyphosate results in increased expression of LHB proteinPMID:22120950
Lhbincreases methylationEXP 6480464CTDGlyphosate results in increased methylation of LHB genePMID:31011160
Lhbincreases expressionISOLhb (Mus musculus)6480464CTDGlyphosate results in increased expression of LHB mRNAPMID:30245445
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