Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2943
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Jun
Name:	Jun proto-oncogene, AP-1 transcription factor subunit

Acc ID:	CHEBI:8093
Term:	phenylephrine
Definition:	A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID:	MESH:D010656

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Jun	affects response to substance	EXP		6480464	CTD	JUN protein affects the susceptibility to Phenylephrine	PMID:11799083
Jun	increases activity	EXP		6480464	CTD	Phenylephrine results in increased activity of JUN protein	PMID:15949472
Jun	increases expression	EXP		6480464	CTD	Phenylephrine results in increased expression of JUN; Phenylephrine results in increased expression of JUN mRNA; Phenylephrine results in increased expression of JUN protein	PMID:12169099 PMID:14764439 PMID:19002563 PMID:19225867 PMID:19443575 PMID:7905536
Jun	increases phosphorylation	EXP		6480464	CTD	Phenylephrine results in increased phosphorylation of JUN protein	PMID:12169099 PMID:20067472
Jun	multiple interactions	EXP		6480464	CTD	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased phosphorylation of JUN protein]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; MAPK3 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; Phenylephrine inhibits the reaction [MAPK7 protein results in increased expression of JUN protein]; Phenylephrine promotes the reaction [JUN protein binds to FOS protein]; pyrazolanthrone inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; RPS6KA5 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]	PMID:11799083 PMID:12574153 PMID:14764439 PMID:19002563 PMID:20067472
Jun	increases expression	ISO	Jun (Mus musculus)	6480464	CTD	Phenylephrine results in increased expression of JUN mRNA	PMID:16690042
Jun	multiple interactions	ISO	Jun (Mus musculus)	6480464	CTD	[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]	PMID:10710348

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