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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:28073
Term: chromium atom
Definition: A chromium group element atom that has atomic number 24.
Chemical ID: MESH:D002857
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junincreases phosphorylationISOJun (Mus musculus)6480464CTDChromium results in increased phosphorylation of JUN proteinPMID:18569013
Junmultiple interactionsISOJun (Mus musculus)6480464CTD[Copper co-treated with Lead co-treated with Cadmium co-treated with Zinc co-treated with Mercury co-treated with Chromium co-treated with Manganese co-treated with Nickel] results in increased expression of JUN protein; Acetylcysteine inhibits the reaction [Chromium results in increased phosphorylation of JUN protein]PMID:18569013 PMID:28035397
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDChromium affects the reaction [JUN protein binds to CREBBP protein]PMID:10593907
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