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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2940
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jak3
Name: Janus kinase 3
Acc ID: CHEBI:28869
Term: menadione
Definition: A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.
Chemical ID: MESH:D024483
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jak3increases phosphorylationISOJAK3 (Homo sapiens)6480464CTDVitamin K 3 results in increased phosphorylation of JAK3 proteinPMID:24106086
Jak3multiple interactionsISOJAK3 (Homo sapiens)6480464CTD[[Vitamin K 3 results in increased phosphorylation of JAK3 protein] which results in increased phosphorylation of and affects the localization of ELAVL1 protein] inhibits the reaction [ELAVL1 protein binds to and results in decreased degradation of SIRT1 mRNA]; [[Vitamin K 3 results in increased phosphorylation of JAK3 protein] which results in increased phosphorylation of and affects the localization of ELAVL1 protein] inhibits the reaction [ELAVL1 protein binds to and results in decreased degradation of VHL mRNA]; [Vitamin K 3 results in increased phosphorylation of JAK3 protein] which results in increased phosphorylation of and affects the localization of ELAVL1 protein; JAK3 protein promotes the reaction [Vitamin K 3 results in increased phosphorylation of ELAVL1 protein]PMID:24106086
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