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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2939
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jak2
Name: Janus kinase 2
Acc ID: CHEBI:16348
Term: 3-nitropropanoic acid
Definition: A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.
Chemical ID: MESH:C015392
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jak2increases phosphorylationEXP 6480464CTD3-nitropropionic acid results in increased phosphorylation of JAK2 proteinPMID:38513929
Jak2multiple interactionsEXP 6480464CTDmethyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of JAK2 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of JAK2 protein]PMID:38513929
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