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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:6651
Term: malathion
Definition: A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.
Chemical ID: MESH:D008294
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6decreases expressionEXP 6480464CTDMalathion results in decreased expression of IL6 proteinPMID:32495713
Il6increases expressionEXP 6480464CTDMalathion results in increased expression of IL6 mRNAPMID:24810974 PMID:25180440
Il6multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Malathion results in increased expression of IL6 mRNA]PMID:24810974
Il6increases expressionISOIL6 (Homo sapiens)6480464CTDMalathion results in increased expression of IL6 mRNAPMID:37047231
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