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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:42977
Term: 25-hydroxycholesterol
Definition: A 25-hydroxy steroid that has formula 402.65294.
Chemical ID: MESH:C007997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6multiple interactionsEXP 6480464CTD25-hydroxycholesterol inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]PMID:27052460
Il6increases secretionISOIL6 (Homo sapiens)6480464CTD25-hydroxycholesterol results in increased secretion of IL6 proteinPMID:11851725
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTD25-hydroxycholesterol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]PMID:11851725
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