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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:17303
Term: morphine
Definition: A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Chemical ID: MESH:D009020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDMorphine results in increased expression of IL1B mRNA; Morphine results in increased expression of IL1B proteinPMID:12427855 PMID:21081778 PMID:22713680
Il1bincreases secretionEXP 6480464CTDMorphine results in increased secretion of IL1B proteinPMID:20178837
Il1bmultiple interactionsEXP 6480464CTDAnti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL1B mRNA]PMID:21081778 PMID:22713680
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDMorphine results in increased expression of IL1B proteinPMID:24756886 PMID:37394652
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTDcorilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]PMID:24756886 PMID:37394652
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