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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Icam1affects response to substanceISOIcam1 (Mus musculus)6480464CTDICAM1 protein affects the susceptibility to CyclophosphamidePMID:11591119
Icam1multiple interactionsISOIcam1 (Mus musculus)6480464CTDCyclophosphamide inhibits the reaction [Paraquat results in increased expression of ICAM1 mRNA]PMID:36031164
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