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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2810
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hnf4a
Name: hepatocyte nuclear factor 4, alpha
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hnf4amultiple interactionsEXP 6480464CTD[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of HNF4A mRNAPMID:16415329
Hnf4adecreases expressionISOHnf4a (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of HNF4A proteinPMID:16002565
Hnf4aincreases response to substanceISOHnf4a (Mus musculus)6480464CTDHNF4A protein results in increased susceptibility to LipopolysaccharidesPMID:21131441
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