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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:8273
Term: plumbagin
Definition: A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively.
Chemical ID: MESH:C014758
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1multiple interactionsEXP 6480464CTDplumbagin promotes the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]PMID:32691977
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDplumbagin results in increased expression of HMOX1 mRNA; plumbagin results in increased expression of HMOX1 proteinPMID:20028456
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [plumbagin results in increased expression of HMOX1 protein]; NFE2L2 mRNA affects the reaction [plumbagin results in increased expression of HMOX1 mRNA]; wortmannin inhibits the reaction [plumbagin results in increased expression of HMOX1 protein]PMID:20028456
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