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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1affects expressionEXP 6480464CTDKetoconazole affects the expression of HMOX1 mRNAPMID:18289764
Hmox1increases expressionEXP 6480464CTDKetoconazole results in increased expression of HMOX1 mRNAPMID:37077353
Hmox1multiple interactionsEXP 6480464CTD[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of HMOX1 protein; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]PMID:12763371 PMID:31168027
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTDKetoconazole inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]PMID:22659318
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