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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1affects expressionEXP 6480464CTDCyclophosphamide affects the expression of HMOX1 mRNAPMID:11906922
Hmox1decreases expressionEXP 6480464CTDCyclophosphamide results in decreased expression of HMOX1 mRNA; Cyclophosphamide results in decreased expression of HMOX1 proteinPMID:20038455 PMID:20433640 PMID:32197949 PMID:32456565
Hmox1increases expressionEXP 6480464CTDCyclophosphamide results in increased expression of HMOX1 mRNA; Cyclophosphamide results in increased expression of HMOX1 proteinPMID:17979934 PMID:18206168 PMID:18246545 PMID:20038455 PMID:37419146
Hmox1multiple interactionsEXP 6480464CTD[astaxanthine co-treated with Cyclophosphamide] results in increased expression of HMOX1 protein; Cilostazol inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 mRNA]; Cilostazol inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; Hemin inhibits the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; Quercetin inhibits the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]PMID:17979934 PMID:18206168 PMID:20038455 PMID:20433640 PMID:32197949 PMID:32456565 PMID:37419146
Hmox1decreases expressionISOHMOX1 (Homo sapiens)6480464CTDCyclophosphamide results in decreased expression of HMOX1 proteinPMID:19952508
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