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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:31812
Term: meglumine amidotrizoate
Definition: The N-methylglucamine salt of amidotrizoic acid. Both the sodium and the meglumine salts of amidotrizoic acid have been widely used as water-soluble radioopaque media in diagnostic radiography. The use of a mixture of the two salts is often preferred, as adverse effects can be reduced.
Chemical ID: MESH:D003974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1decreases expressionEXP 6480464CTDDiatrizoate Meglumine results in decreased expression of HMOX1 proteinPMID:31173751
Hmox1increases expressionEXP 6480464CTDDiatrizoate Meglumine results in increased expression of HMOX1 mRNAPMID:28412091
Hmox1multiple interactionsEXP 6480464CTDLansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of HMOX1 mRNA]PMID:28412091
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