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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:29693
Term: thiostrepton
Definition: A heterodetic cyclic peptide, in which the cyclisation step involves a formal lactonisation between the carboxy group of a quinaldic acid-based residue and a secondary alcohol. An antibiotic that inhibits bacterial protein synthesis. Also acts as an antitumor agent.
Chemical ID: MESH:D013883
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDThiostrepton results in increased expression of HMOX1 mRNA; Thiostrepton results in increased expression of HMOX1 proteinPMID:22321511 PMID:32661532
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTDMTF1 protein affects the reaction [Thiostrepton results in increased expression of HMOX1 mRNA]PMID:32661532
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