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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gusb
Name: glucuronidase, beta
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gusbdecreases expressionEXP 6480464CTDCyclophosphamide results in decreased expression of GUSB proteinPMID:17686619
Gusbincreases activityEXP 6480464CTDCyclophosphamide results in increased activity of GUSB proteinPMID:25451569
Gusbmultiple interactionsEXP 6480464CTDAnthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of GUSB protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in increased activity of GUSB protein]PMID:25451569
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