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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstp1
Name: glutathione S-transferase pi 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstp1decreases response to substanceEXP 6480464CTDGSTP1 protein results in decreased susceptibility to DoxorubicinPMID:11455017
Gstp1increases expressionEXP 6480464CTD[Doxorubicin results in increased expression of NFE2L2 protein] which results in increased expression of GSTP1 mRNAPMID:24211725
Gstp1increases oxidationEXP 6480464CTDDoxorubicin results in increased oxidation of GSTP1 proteinPMID:28818578
Gstp1affects response to substanceISOGSTP1 (Homo sapiens)6480464CTDGSTP1 protein affects the susceptibility to DoxorubicinPMID:16217747 PMID:18225754
Gstp1decreases expressionISOGstp1 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of GSTP1 proteinPMID:29775573
Gstp1decreases response to substanceISOGstp1 (Mus musculus)6480464CTDGSTP1 protein results in decreased susceptibility to DoxorubicinPMID:16289015
Gstp1decreases response to substanceISOGSTP1 (Homo sapiens)6480464CTDGSTP1 mRNA results in decreased susceptibility to Doxorubicin; GSTP1 promoter modified form results in decreased susceptibility to Doxorubicin; GSTP1 protein results in decreased susceptibility to DoxorubicinPMID:15448748 PMID:16356834 PMID:24675091
Gstp1increases expressionISOGSTP1 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of GSTP1 mRNA; Doxorubicin results in increased expression of GSTP1 proteinPMID:14623254 PMID:15205334 PMID:15533597 PMID:16579640 PMID:29803840
Gstp1multiple interactionsISOGstp1 (Mus musculus)6480464CTD[copper (N-2-hydroxyacetophenone)glycinate results in decreased expression of GSTP1 protein] which results in increased susceptibility to Doxorubicin; indole-3-carbinol inhibits the reaction [Doxorubicin results in decreased expression of GSTP1 protein]PMID:16289015 PMID:29775573
Gstp1multiple interactionsISOGSTP1 (Homo sapiens)6480464CTD[GCLC protein co-treated with GCLM protein] promotes the reaction [GSTP1 protein results in decreased susceptibility to Doxorubicin]; Doxorubicin promotes the reaction [GATA1 protein binds to GSTP1 promoter]; GSTP1 gene SNP results in increased susceptibility to [Carmustine co-treated with Doxorubicin co-treated with Cyclophosphamide co-treated with Melphalan]; Haloperidol inhibits the reaction [GSTP1 protein results in decreased susceptibility to Doxorubicin]PMID:10900222 PMID:12791655 PMID:14623254 PMID:15946544
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