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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2756
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstm2
Name: glutathione S-transferase mu 2
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm2increases expressionEXP 6480464CTDPhenobarbital results in increased expression of GSTM2 mRNA; Phenobarbital results in increased expression of GSTM2 proteinPMID:12082028 PMID:12832660 PMID:17381134 PMID:19162173 PMID:19695238 PMID:8242872
Gstm2increases expressionISOGstm2 (Mus musculus)6480464CTDPhenobarbital results in increased expression of GSTM2 mRNA; Phenobarbital results in increased expression of GSTM2 proteinPMID:19270015 PMID:19482888 PMID:20118494 PMID:20403969 PMID:21335049 PMID:23091169 PMID:26519955 PMID:28541575
Gstm2increases expressionISOGSTM2 (Homo sapiens)6480464CTDPhenobarbital results in increased expression of GSTM2 proteinPMID:28541575
Gstm2multiple interactionsISOGstm2 (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of GSTM2 mRNA; [Phenobarbital co-treated with CTNNB1 protein mutant form] results in increased expression of GSTM2 mRNA; NR1I3 protein affects the reaction [Phenobarbital results in increased expression of GSTM2 mRNA]PMID:19482888 PMID:20118494 PMID:24535843
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