GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gstm2 | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of GSTM2 protein | PMID:12361703 | Gstm2 | affects expression | ISO | Gstm2 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of GSTM2 mRNA; Tetrachlorodibenzodioxin affects the expression of GSTM5 mRNA | PMID:20702594 PMID:21570461 PMID:26377647 | Gstm2 | increases expression | ISO | Gstm2 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of GSTM2 mRNA | PMID:18172886 PMID:18796159 PMID:19474220 PMID:21851831 PMID:22496397 | Gstm2 | multiple interactions | ISO | Gstm2 (Mus musculus) | 6480464 | CTD | [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of GSTM2 mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM2 mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM5 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GSTM5 mRNA; AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTM2 mRNA]; NFE2L2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTM2 mRNA] | PMID:16214954 PMID:17942748 PMID:19474220 PMID:22496397 PMID:28433925 | | ||||||||||||||||||||||
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