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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2755
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstm1
Name: glutathione S-transferase mu 1
Acc ID: CHEBI:2948
Term: azathioprine
Definition: A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Chemical ID: MESH:D001379
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm1affects metabolic processingISOGSTM1 (Homo sapiens)6480464CTDGSTM1 protein affects the metabolism of AzathioprinePMID:18155239 PMID:20434437
Gstm1affects response to substanceISOGSTM1 (Homo sapiens)6480464CTDGSTM1 gene polymorphism affects the susceptibility to AzathioprinePMID:17206640
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