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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2754
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsta2
Name: glutathione S-transferase alpha 2
Acc ID: CHEBI:77319
Term: oltipraz
Definition: A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.
Chemical ID: MESH:C026209
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsta2increases expressionEXP 6480464CTDoltipraz results in increased expression of GSTA2 mRNA; oltipraz results in increased expression of GSTA2 proteinPMID:12242683 PMID:12509401 PMID:15155840 PMID:15870285 PMID:9203627
Gsta2multiple interactionsEXP 6480464CTD2-tert-butylhydroquinone inhibits the reaction [oltipraz results in increased expression of GSTA2 mRNA]; Dexamethasone inhibits the reaction [oltipraz results in increased expression of GSTA2 mRNA]; Dexamethasone inhibits the reaction [oltipraz results in increased expression of GSTA2 protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased expression of GSTA2 protein]; oltipraz promotes the reaction [CEBPB protein binds to GSTA2 promoter]PMID:12509401 PMID:15155840 PMID:15319326 PMID:15870285
Gsta2increases expressionISOGsta2 (Mus musculus)6480464CTDoltipraz results in increased expression of GSTA2 proteinPMID:11309284
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