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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2754
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsta2
Name: glutathione S-transferase alpha 2
Acc ID: CHEBI:16170
Term: mercury(0)
Definition: Elemental mercury of oxidation state zero.
Chemical ID: MESH:D008628
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsta2increases expressionEXP 6480464CTDMercury results in increased expression of GSTA2 mRNAPMID:12167210
Gsta2affects activityISOGsta2 (Mus musculus)6480464CTDMercury affects the activity of GSTA2 proteinPMID:15297030
Gsta2multiple interactionsISOGsta2 (Mus musculus)6480464CTDMercury inhibits the reaction [Benzo(a)pyrene results in increased activity of GSTA2 protein]; Mercury inhibits the reaction [beta-Naphthoflavone results in increased activity of GSTA2 protein]; Mercury promotes the reaction [Benzo(a)pyrene results in increased expression of GSTA2 mRNA]; Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of GSTA2 mRNA]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of GSTA2 mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA2 mRNA]PMID:15297030
Gsta2multiple interactionsISOGSTA2 (Homo sapiens)6480464CTD[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in increased expression of GSTA2 mRNAPMID:32949613
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