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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2752
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gss
Name: glutathione synthetase
Acc ID: CHEBI:9907
Term: ursodeoxycholic acid
Definition: A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.
Chemical ID: MESH:D014580
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gssincreases expressionISOGSS (Homo sapiens)6480464CTDUrsodeoxycholic Acid results in increased expression of GSS mRNAPMID:19073151
Gssmultiple interactionsISOGSS (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]]; Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GSS mRNA]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]PMID:19073151 PMID:20146260
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