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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:48041
Term: microcystin
Definition: A family of cyclic heptapeptide hepatotoxins produced by a number of cyanobacteria, the most notable of which is Microcystis, from which the name of the family is derived. Microcystins consist of a heptapeptide macrocycle made up of five non-protein amino acids and two protein amino acids.
Chemical ID: MESH:D052998
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1increases expressionEXP 6480464CTDMicrocystins analog results in increased expression of GPX1 mRNAPMID:24964298
Gpx1multiple interactionsEXP 6480464CTDButhionine Sulfoximine promotes the reaction [Microcystins analog results in increased expression of GPX1 mRNA]PMID:24964298
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