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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:254496
Term: 7,12-dimethyltetraphene
Definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Chemical ID: MESH:D015127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1decreases activityEXP 6480464CTD9,10-Dimethyl-1,2-benzanthracene results in decreased activity of GPX1 proteinPMID:30027798
Gpx1multiple interactionsEXP 6480464CTDbrucine inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of GPX1 protein]PMID:30027798
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