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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2703
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Glp1r
Name: glucagon-like peptide 1 receptor
Acc ID: CHEBI:17489
Term: 3',5'-cyclic AMP
Definition: A 3',5'-cyclic purine nucleotide having having adenine as the nucleobase.
Chemical ID: MESH:D000242
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Glp1rmultiple interactionsISOGlp1r (Mus musculus)6480464CTD[GCG protein modified form binds to and results in increased activity of GLP1R protein] which results in increased abundance of Cyclic AMPPMID:18669601
Glp1rmultiple interactionsISOGLP1R (Homo sapiens)6480464CTD[[GCG protein binds to and results in increased activity of GLP1R protein] which results in increased chemical synthesis of Cyclic AMP] promotes the reaction [ARRB2 protein binds to GLP1R protein]; [[GCG protein binds to and results in increased activity of GLP1R protein] which results in increased chemical synthesis of Cyclic AMP] promotes the reaction [GRK2 protein binds to GLP1R protein]; [[GCG protein binds to and results in increased activity of GLP1R protein] which results in increased chemical synthesis of Cyclic AMP] which affects the localization of ARRB2 protein; [GCG protein binds to and results in increased activity of GLP1R protein] which results in increased chemical synthesis of Cyclic AMPPMID:25191754
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