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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2690
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:43355
Term: indoxyl sulfate
Definition: An aryl sulfate that is indoxyl in which the hydroxyl hydrogen is substituted by a sulfo group.
Chemical ID: MESH:D007200
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1decreases expressionEXP 6480464CTDIndican results in decreased expression of GJA1 mRNA; Indican results in decreased expression of GJA1 protein modified formPMID:32045570
Gja1multiple interactionsEXP 6480464CTDIndican results in decreased expression of and affects the localization of GJA1 protein; pyrazolanthrone inhibits the reaction [Indican results in decreased expression of and affects the localization of GJA1 protein]; pyrazolanthrone inhibits the reaction [Indican results in decreased expression of GJA1 mRNA]PMID:32045570
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