Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2690
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1increases expressionEXP 6480464CTDFulvestrant results in increased expression of GJA1 mRNAPMID:36931579
Gja1decreases expressionISOGJA1 (Homo sapiens)6480464CTDfulvestrant results in decreased expression of GJA1 mRNA; fulvestrant results in decreased expression of GJA1 proteinPMID:29180066
Gja1multiple interactionsISOGJA1 (Homo sapiens)6480464CTD[Fulvestrant co-treated with U 0126] affects the reaction [[Acetylcysteine co-treated with ascorbate-2-phosphate] affects the expression of GJA1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Fulvestrant results in decreased expression of GJA1 protein]; Fulvestrant affects the reaction [[Acetylcysteine co-treated with ascorbate-2-phosphate] affects the expression of GJA1 mRNA]; Fulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein]; MAP2K3 promotes the reaction [Fulvestrant results in decreased expression of GJA1 protein]; MAP2K6 promotes the reaction [Fulvestrant results in decreased expression of GJA1 protein]; SB 203580 inhibits the reaction [Fulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein]]; SB 203580 inhibits the reaction [Fulvestrant results in decreased expression of GJA1 mRNA]; SB 203580 inhibits the reaction [Fulvestrant results in decreased expression of GJA1 protein]PMID:29180066 PMID:32610363
Go Back to source page   Continue to Ontology report