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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2690
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1increases expressionEXP 6480464CTDGenistein results in increased expression of GJA1 mRNAPMID:15901920
Gja1multiple interactionsEXP 6480464CTD[Diethylhexyl Phthalate co-treated with Genistein] results in increased expression of GJA1 mRNA; Genistein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of GJA1 mRNA]PMID:26316063 PMID:32533902
Gja1multiple interactionsISOGJA1 (Homo sapiens)6480464CTDGenistein inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]PMID:23452621
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