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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2679
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gfap
Name: glial fibrillary acidic protein
Acc ID: CHEBI:8207
Term: (+)-pilocarpine
Definition: The (+)-enantiomer of pilocarpine.
Chemical ID: MESH:D010862
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gfapdecreases expressionEXP 6480464CTDPilocarpine results in decreased expression of GFAP proteinPMID:25101675
Gfapincreases expressionEXP 6480464CTDPilocarpine results in increased expression of GFAP proteinPMID:30542433
Gfapmultiple interactionsEXP 6480464CTD1,1-dimethylbutyl-1-deoxy-Delta(9)-THC promotes the reaction [Pilocarpine results in increased expression of GFAP protein]; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of GFAP mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of GFAP protein; iodopravadoline inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC promotes the reaction [Pilocarpine results in increased expression of GFAP protein]]PMID:30542433 PMID:31018114
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