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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2677
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gdnf
Name: glial cell derived neurotrophic factor
Acc ID: CHEBI:8633
Term: puerarin
Definition: A hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 7 and 4' and a beta-D-glucopyranosyl residue at position 8 via a C-glycosidic linkage.
Chemical ID: MESH:C033607
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gdnfmultiple interactionsISOGDNF (Homo sapiens)6480464CTD4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [puerarin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein]]; puerarin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein]PMID:27796870
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