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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2670
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gck
Name: glucokinase
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gckdecreases activityEXP 6480464CTDDiethylhexyl Phthalate results in decreased activity of GCK proteinPMID:25280772
Gckdecreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of GCK mRNAPMID:25280772
Gckdecreases expressionISOGck (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of GCK mRNAPMID:19245819
Gckmultiple interactionsISOGck (Mus musculus)6480464CTD[Streptozocin co-treated with Dietary Fats co-treated with Diethylhexyl Phthalate] results in decreased expression of GCK proteinPMID:33484791
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