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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2661
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gapdh
Name: glyceraldehyde-3-phosphate dehydrogenase
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gapdhdecreases expressionISOGAPDH (Homo sapiens)6480464CTDCisplatin results in decreased expression of GAPDH mRNAPMID:29690507
Gapdhincreases expressionISOGAPDH (Homo sapiens)6480464CTDCisplatin results in increased expression of GAPDH proteinPMID:21924258
Gapdhmultiple interactionsISOGAPDH (Homo sapiens)6480464CTD[eprenetapopt co-treated with Cisplatin] inhibits the reaction [Oxygen deficiency results in increased expression of GAPDH mRNA]; [eprenetapopt co-treated with Cisplatin] results in decreased expression of GAPDH mRNA; Cisplatin inhibits the reaction [Oxygen deficiency results in increased expression of GAPDH mRNA]PMID:29690507
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