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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2632
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fshr
Name: follicle stimulating hormone receptor
Acc ID: CHEBI:6427
Term: leuprolide
Definition: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the acetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
Chemical ID: MESH:D016729
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fshrmultiple interactionsISOFshr (Mus musculus)6480464CTD[Leuprolide co-treated with Testosterone] results in decreased expression of FSHR mRNAPMID:16032706
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