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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2628
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fosl2
Name: FOS like 2, AP-1 transcription factor subunit
Acc ID: CHEBI:2679
Term: amphetamine
Definition: A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
Chemical ID: MESH:D000661
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosl2decreases expressionISOFOSL2 (Homo sapiens)6480464CTDAmphetamine results in decreased expression of FOSL2 proteinPMID:15814102
Fosl2multiple interactionsISOFOSL2 (Homo sapiens)6480464CTDAmphetamine promotes the reaction [JUND protein binds to FOSL2 protein]; Amphetamine results in increased activity of [JUND protein binds to FOSL2 protein]PMID:15814102
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