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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2624
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fn1
Name: fibronectin 1
Acc ID: CHEBI:59877
Term: enalaprilat dihydrate
Definition: The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.
Chemical ID: MESH:D015773
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fn1decreases expressionEXP 6480464CTDEnalaprilat results in decreased expression of FN1 mRNA; Enalaprilat results in decreased expression of FN1 proteinPMID:21795644
Fn1multiple interactionsISOFn1 (Mus musculus)6480464CTDEnalaprilat inhibits the reaction [Glucose results in increased expression of FN1 mRNA]PMID:14520012
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