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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2620
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Flg
Name: filaggrin
Acc ID: CHEBI:34240
Term: 2,4-Dihydroxybenzophenone
Definition: A benzophenone that has formula C13H10O3.
Chemical ID: MESH:C121479
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Flgaffects response to substanceISOFLG (Homo sapiens)6480464CTDFLG gene mutant form affects the susceptibility to 2,4-dihydroxybenzophenonePMID:30245359
Flgmultiple interactionsISOFLG (Homo sapiens)6480464CTD[FLG gene mutant form affects the susceptibility to 2,4-dihydroxybenzophenone] which results in decreased secretion of FSHB protein; [FLG gene mutant form affects the susceptibility to 2,4-dihydroxybenzophenone] which results in increased secretion of Estradiol; [FLG gene mutant form affects the susceptibility to 2,4-dihydroxybenzophenone] which results in increased secretion of TestosteronePMID:30245359
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